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KMID : 0363320090300030612
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Journal of Korean Oriental Internal Medicine
2009 Volume.30 No. 3 p.612 ~ p.623
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The Protective Effects of Sopung-tang on Brain Damage in Photothrombotic Ischemia Mouse Model
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Jang Seok-O
Choi Ji-Hye
Lee Dong-Yeop
Choi Yong-Jun
Lee In
Moon Byung-Soon
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Abstract
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Objectives : The water extract of Sopung-tang (SPT) has been traditionally used in the treatment of acute stroke in Oriental Medicine. Pro-inflammatory cytokines play a critical role in the onset of post-ischemic inflammatory cascades. The present study was designed to investigate the effects of SPT on pro-inflammatory cytokine production in a photothrombotic ischemia mouse model.
Methods : After SPT oral administration to the mice for five days, with using Rose Bengal and cold light, photothrombotic ischemia lesion was induced in stereotactically held male BALB/c mice. Also, results including, gross finding lesion size, histopathological finding changes, and inflammatory cytokine expression changes from the photothrombotic ischemia mouse model were observed.
Results : The photothrombotic ischemia lesion was decreased by the oral injection of SPT. Also, SPT inhibited the expression of TNF-, IL-, IL-6, the active form of caspase-3 protease, and transglutaminase-2 in the photothrombotic ischemia lesion.
Conclusions : These results suggest that SPT protects the ischemic death of brain cells through suppression of the production of anti-inflammatory cytokines and catalytic activation of caspase-3 protease in the photothrombotic ischemia mouse model.
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KEYWORD
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Sopung-tang(SPT), photothrombotic ischemia mouse model, anti-inflammatory cytokines, caspase-3 protease
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